Cancer Immunotherapy Related Molecules: Introduction
For the different functions in cancer immunotherapy, these molecules were divided into some groups: Immune checkpoints, monoclonol antibodies for targets, cytokines and tumer antigens. These molecules belong to one or more groups.
Cancer Immuotherapy Related Molecules: Immune Checkpoint
Immunotherapy has been regarded as the most exciting development in cancer treatment for a long time after years of scientific research and clinical trails. What is immunotherapy? Immunotherapy is a uleatment that is designed to harness the ability of the body's immune system to combat infection or disease, such as cancer, allergy and autoimmune disease. Vaccines, monoclonal antibodies, cytokines are the representative types of immunotherapy uleatments. Recently immune checkpoints and chimeric antigen receptor (CAR) T-cell have drawn attention from scientists with numerous clinical success.
Depending on the type of treatment, various side effects can arise as a result of using immunotherapy. Side effects include flu-like symptoms, muscle aches, fever, appetite loss, weakness, diarrhea, nausea and vomiting. A rash may develop and some people bruise or bleed easily. These side effects are generally short-term, but patients may need to stay in hospital if they develop severe problems.
Cancer Immunotherapy: Background
Cancer Immunotherapy has become an important part of treating some types of cancer. Newer types of immune treatments are now being studied, and they'll impact how we uleat cancer in the future. What is cancer immunotherapy? Cancer immunotherapy is uleatment that uses certain parts of a person's immune system to fight cancer. This can be done in a couple of ways: Stimulating your own immune system to work harder or smarter to attack cancer cells; Giving you immune system components, such as man-made immune system proteins. Many types of immunotherapy have been developped to uleat cancer: monoclonal antibodies, vaccines, cytokines delivery and so on. And a lot of drugs have been deveolpped or researched to attack different cancers.
Autoimmune Disease Immunotherapy Related Molecules: HSP60
HSP60 Implicated in mitochondrial protein import and macromolecular assembly. May facilitate the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under suless conditions in the mitochondrial maulix. Interacts with HRAS. Interacts with HBV protein X and HTLV-1 protein p40tax. Belongs to the chaperonin (HSP60) family. some new research has indicated that HSP60 possibly plays a role in a "danger signal cascade" immune response. There is also mounting evidence that it plays a role in autoimmune disease.
Autoimmune Disease Immunotherapy Related Molecules: GAD65
GAD65 is the product of a gene located on Chromosome 10 with containing 585 aminoacids. In T1D autoimmunity, only GAD65 is antigenic despite the higher expression of GAD67 in islet beta cells. Interestingly, in stiff man syndrome, the other well documented case of GAD antigenicity, GAD65 is also the major autoantigen. The differences in the antigenicity of the GAD isoforms merits scrutiny, particularly in view of the potential of GAD 65 to be used in immunotherapies.
Immunotherapies definition. Dictionary.com. Retrieved 2009-06-02.
Jeffrey S. Weber et al. Toxicities of Immunotherapy for the Practitioner. American Society of Clinical Oncology. 2015, 33(18): 2092-2099.
Mellman I et al. Cancer immunotherapy comes of age. Nature, 2011, 480(7378): 480-489.