Carboxypeptidase B1 (Protein | Antibody | cDNA Clone | ELISA Kit)

All Carboxypeptidase B1 reagents are produced in house and quality controlled, including 12 Carboxypeptidase B1 Antibody, 3 Carboxypeptidase B1 ELISA, 41 Carboxypeptidase B1 Gene, 2 Carboxypeptidase B1 Lysate, 2 Carboxypeptidase B1 Protein, 2 Carboxypeptidase B1 qPCR. All Carboxypeptidase B1 reagents are ready to use.

Carboxypeptidase B1 Protein (2)

Carboxypeptidase B1 Antibody (12)

Carboxypeptidase B1 ELISA Kit & Match Antibody ELISA Pair Set (3)

Carboxypeptidase B1 cDNA Clone (41)

NM_001871.2
NM_029706.1

Carboxypeptidase B1 Lysate (2)

Carboxypeptidase B1 Background

Carboxypeptidase B1, also well known as pancreatic procarboxypeptidase B (PCPB), is a highly pancreas -specific protein (PASP), and has been identified previously as a serum marker for acute pancreatitis and pancreatic graft rejection. As the prototype for those human exopeptidases that cleave off basic C-terminal residues, CPB1 specifically cleaves the C-terminal Arg and Lys residues with a preference for Arg. The B1 and B2 forms of procarboxypeptidase B differ from each other mainly in isoelectric point.The deduced amino acid sequence of PCPB predicts a 416-amino acid preproenzyme consisting of a 15-aa signal peptide, a 95-aa activation peptide and a 37-aa mature chain. The secreted PCPB zymogen is converted to enzymatically active CPB1 by limited proteolysis by trypsin.

Carboxypeptidase B1 References

  • Yamamoto, K.K. et al., 1992, J. Biol. Chem. 267: 2575-2581.
  • Pezzilli, R. et al., 1994, Digestion. 55: 73-77.
  • Barbosa Pereira, P.J. et al., 2002, J. Mol. Biol. 321: 537-547.