Carbonic Anhydrase IV (Protein | Antibody | cDNA Clone | ELISA Kit)

All Carbonic Anhydrase IV reagents are produced in house and quality controlled, including 5 Carbonic Anhydrase IV Antibody, 25 Carbonic Anhydrase IV Gene, 1 Carbonic Anhydrase IV IP Kit, 3 Carbonic Anhydrase IV Lysate, 3 Carbonic Anhydrase IV Protein, 2 Carbonic Anhydrase IV qPCR. All Carbonic Anhydrase IV reagents are ready to use.

Carbonic Anhydrase IV Protein (3)

Carbonic Anhydrase IV Antibody (5)

Carbonic Anhydrase IV cDNA Clone (25)

NM_000717.3
NM_007607.2

Carbonic Anhydrase IV Lysate (3)

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Carbonic Anhydrase IV Background

The carbonic anhydrases (or carbonate dehydratases) are classified as metalloenzyme for its zinc ion prosthetic group and form a family of enzymes that catalyze the rapid interconversion of carbon dioxide and water to bicarbonate and protons, a reversible reaction that takes part in maintaining acid-base balance in blood and other tissues. The carbonic anhydrasekl (CA) family consists of at least 11 enzymatically active members and a few inactive homologous proteins. Carbonic anhydrase IV (CAIV) is a membrane-associated enzyme anchored to plasma membrane surfaces by a phosphatidylinositol glycan linkage. CAIV is a high-activity isozyme in CO2 hydration comparable to that of CAII. Furthermore, CAIV is more active in HCO3- dehydration than is CAII. However, the esterase activity of CAIV is decreased 15-fold compared to CAII.

Carbonic Anhydrase IV References

  • Lehtonen J, et al. (2004) Characterization of CA XIII, a Novel Member of the Carbonic Anhydrase Isozyme Family. The Journal of Biological Chemistry. 279: 2719-27.
  • Lindskog S. (1997) Structure and mechanism of carbonic anhydrase. Pharmacology & Therapeutics. 74(1):1-20.
  • Baird TT, et al. (1997) Catalysis and Inhibition of Human Carbonic Anhydrase IV. Biochemistry. 36 (9): 2669-78.