BMP4 (Protein | Antibody | cDNA Clone | ELISA Kit)

All BMP4 reagents are produced in house and quality controlled, including 1 BMP4 Antibody, 65 BMP4 Gene, 1 BMP4 Lysate, 1 BMP4 Protein, 2 BMP4 qPCR. All BMP4 reagents are ready to use.

BMP4 Protein (1)

BMP4 Antibody (1)

BMP4 cDNA Clone (65)

NM_130850.3
NM_007554.2
XM_001084801.2
NP_571417.1
XM_859074.2

BMP4 Lysate (1)

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BMP4 Background

BMP4 (bone morphogenetic protein-4)-directed differentiation of human embryonic stem cells (ESCd). Autophagy is a conserved catabolic process with complicated roles in tumor development. Bone morphogenetic protein 4 (BMP4), a member of the transforming growth factor (TGF-β) family of regulatory proteins, plays a crucial role in human malignancies. BMP4 treatment promoted HCC cells proliferation and induced autophagy. Mechanistic study revealed that the induction of autophagy by BMP4 was mediated through activating the JNK1/Bcl2 pathway. And the JNK1 inhibitor and knockdown of JNK1 could attenuate autophagy induced by BMP4 and eliminated BMP4-promoted HCC cells growth. BMP4 promoted HCC proliferation by autophagy activation through JNK1/Bcl-2 signaling.